Caenorhabditis elegans in anthelmintic research–Old model, new perspectives SR Hahnel, CM Dilks, I Heisler, EC Andersen, D Kulke International journal for parasitology: drugs and drug resistance 14, 237-248, 2020 | 54 | 2020 |
Reprogramming the biosynthesis of cyclodepsipeptide synthetases to obtain new enniatins and beauvericins S Zobel, S Boecker, D Kulke, D Heimbach, V Meyer, RD Süssmuth ChemBioChem 17 (4), 283-287, 2016 | 52 | 2016 |
Dirofilaria immitis Microfilariae and Third-Stage Larvae Induce Canine NETosis Resulting in Different Types of Neutrophil Extracellular Traps T Muñoz-Caro, I Conejeros, E Zhou, A Pikhovych, U Gärtner, ... Frontiers in Immunology 9, 968, 2018 | 47 | 2018 |
Characterization of the Ca2+-Gated and Voltage-Dependent K+-Channel Slo-1 of Nematodes and Its Interaction with Emodepside D Kulke, G von Samson-Himmelstjerna, SM Miltsch, AJ Wolstenholme, ... PLoS neglected tropical diseases 8 (12), e3401, 2014 | 47 | 2014 |
Microfilariae trigger eosinophil extracellular DNA traps in a dectin-1-dependent manner A Ehrens, B Lenz, AL Neumann, S Giarrizzo, JJ Reichwald, ... Cell reports 34 (2), 2021 | 39 | 2021 |
Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration J Krücken, L Holden-Dye, J Keiser, RK Prichard, S Townson, ... PLoS Pathogens 17 (7), e1009682, 2021 | 38 | 2021 |
Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel SS Kashyap, S Verma, D Voronin, S Lustigman, D Kulke, AP Robertson, ... PLoS Pathogens 15 (9), e1008041, 2019 | 32 | 2019 |
Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1 F3P in dogs PDJ Castro, A Mansour, S Charles, J Hostetler, T Settje, D Kulke, ... International Journal for Parasitology: Drugs and Drug Resistance 13, 22-27, 2020 | 28 | 2020 |
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside MP Hübner, S Townson, S Gokool, S Tagboto, MJ Maclean, GG Verocai, ... International Journal for Parasitology: Drugs and Drug Resistance 17, 27-35, 2021 | 20 | 2021 |
Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: influence of the drug resistance status of the parasite T Berrafato, R Coates, BJ Reaves, D Kulke, AJ Wolstenholme International Journal for Parasitology: Drugs and Drug Resistance 10, 45-50, 2019 | 18 | 2019 |
Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice D Kulke, J Krücken, A Harder, G von Samson-Himmelstjerna PLoS Neglected Tropical Diseases 8 (2), e2698, 2014 | 17 | 2014 |
Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis GS Bah, S Schneckener, SR Hahnel, NH Bayang, H Fieseler, ... PLoS pathogens 17 (6), e1009601, 2021 | 15 | 2021 |
In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial D Kulke, J Krücken, C Welz, G von Samson-Himmelstjerna, A Harder Acta tropica 123 (2), 78-84, 2012 | 13 | 2012 |
In vitro efficacy of cyclooctadepsipepdtides and aminophenylamidines alone and in combination against third-stage larvae and adult worms of Nippostrongylus brasiliensis and … D Kulke, J Krücken, J Demeler, A Harder, H Mehlhorn, ... Parasitology research 112, 335-345, 2013 | 11 | 2013 |
Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans SR Hahnel, WM Roberts, I Heisler, D Kulke, JC Weeks International Journal for Parasitology: Drugs and Drug Resistance 16, 174-187, 2021 | 10 | 2021 |
Comparison of the in vitro susceptibility to emodepside of microfilariae, third stage larvae and adult worms of related filarial nematodes D Kulke, S Townson, D Bloemker, S Frohberger, S Specht, I Scandale, ... Am J Trop Med Hyg 97 (5), 563, 2017 | 7 | 2017 |
In vivo efficacy of PF1022A and nicotinic acetylcholine receptor agonists alone and in combination against Nippostrongylus brasiliensis D Kulke, J Kruecken, A Harder, R Krebber, K Fraatz, H Mehlhorn, ... Parasitology 140 (10), 1252-1265, 2013 | 7 | 2013 |
Nemacol is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter with anthelmintic potential S Harrington, J Pyche, AR Burns, T Spalholz, KT Ryan, RJ Baker, J Ching, ... Nature Communications 14 (1), 1816, 2023 | 6 | 2023 |
Periodicity of Dirofilaria immitis in longterm infections. C Evans, E Burkman, M Dzimianski, A Moorhead, M Savadelis, ... Parasitology Research 116, 2017 | 6 | 2017 |
Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release S Harrington, JJ Knox, AR Burns, KL Choo, A Au, M Kitner, C Haeberli, ... Communications biology 5 (1), 865, 2022 | 5 | 2022 |