| Discovery of 3-(2, 6-dichloro-3, 5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor … V Guagnano, P Furet, C Spanka, V Bordas, M Le Douget, C Stamm, ... Journal of medicinal chemistry 54 (20), 7066-7083, 2011 | 494 | 2011 |
| Discovery of a dihydroisoquinolinone derivative (NVP-CGM097): a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors P Holzer, K Masuya, P Furet, J Kallen, T Valat-Stachyra, S Ferretti, ... Journal of medicinal chemistry 58 (16), 6348-6358, 2015 | 189 | 2015 |
| Influence of shear on lyotropic lamellar phases with different membrane defects J Zipfel, J Berghausen, P Lindner, W Richtering The Journal of Physical Chemistry B 103 (15), 2841-2849, 1999 | 109 | 1999 |
| Polymorphism-integrated approach from high-throughput screening to crystallization optimization R Hilfiker, J Berghausen, F Blatter, A Burkhard, SM De Paul, B Freiermuth, ... Journal of thermal analysis and calorimetry 73, 429-440, 2003 | 102 | 2003 |
| Shear induced structures in lamellar phases of amphiphilic block copolymers J Zipfel, J Berghausen, G Schmidt, P Lindner, P Alexandridis, M Tsianou, ... Physical Chemistry Chemical Physics 1 (17), 3905-3910, 1999 | 91 | 1999 |
| Shear-induced orientations in a lyotropic defective lamellar phase J Berghausen, J Zipfel, P Lindner, W Richtering Europhysics Letters 43 (6), 683, 1998 | 89 | 1998 |
| Discovery of roblitinib (FGF401) as a reversible-covalent inhibitor of the kinase activity of fibroblast growth factor receptor 4 RA Fairhurst, T Knoepfel, N Buschmann, C Leblanc, R Mah, M Todorov, ... Journal of medicinal chemistry 63 (21), 12542-12573, 2020 | 76 | 2020 |
| Influence of water-soluble polymers on the shear-induced structure formation in lyotropic lamellar phases J Berghausen, J Zipfel, P Lindner, W Richtering The Journal of Physical Chemistry B 105 (45), 11081-11088, 2001 | 74 | 2001 |
| Design and development of a cyclic decapeptide scaffold with suitable properties for bioavailability and oral exposure M Fouché, M Schäfer, J Berghausen, S Desrayaud, M Blatter, P Piéchon, ... ChemMedChem 11 (10), 1048-1059, 2016 | 63 | 2016 |
| Accelerated formulation development for nanomilled active pharmaceutical ingredients using a screening approach M Juhnke, J Berghausen, C Timpe Chemical engineering & technology 33 (9), 1412-1418, 2010 | 60 | 2010 |
| N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl) carbamide and its tartrate salt and crystalline forms MB Thygesen, N Schlienger, BR Tolf, CMA Andersson, F Blatter, ... US Patent 7,732,615, 2010 | 57 | 2010 |
| Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl) carbamide and its tartrate salt and crystalline forms M Thygesen, N Schlienger, BR Tolf, CM Andersson, F Blatter, ... US Patent App. 11/417,447, 2006 | 56* | 2006 |
| Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-y1)-N′-(4-(2-methylpropyloxy) phenylmethyl) carbamide and their preparation MB Thygesen, N Schlienger, BR Tolf, F Blatter, J Berghausen US Patent 7,868,176, 2011 | 55 | 2011 |
| Influence of shear on solvated amphiphilic block copolymers with lamellar morphology J Zipfel, J Berghausen, G Schmidt, P Lindner, P Alexandridis, ... Macromolecules 35 (10), 4064-4074, 2002 | 54 | 2002 |
| Rheology and shear orientation of a nematic liquid crystalline side-group polymer with laterally attached mesogenic units J Berghausen, J Fuchs, W Richtering Macromolecules 30 (24), 7574-7581, 1997 | 54 | 1997 |
| Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges A Balk, T Widmer, J Wiest, H Bruhn, JC Rybak, P Matthes, ... Pharmaceutical Research 32, 2154-2167, 2015 | 48 | 2015 |
| Substituted isoquinolinones and quinazolinones J Berghausen, N Buschmann, P Furet, F Gessier, JH Lisztwan, P Holzer, ... US Patent 8,440,693, 2013 | 47 | 2013 |
| Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl) carbamide and its tartrate salt and crystalline forms M Thygesen, N Schlienger, BR Tolf, CM Andersson, F Blatter, ... US Patent App. 11/418,341, 2006 | 44 | 2006 |
| The influence of aqueous content in small scale salt screening—improving hit rate for weakly basic, low solubility drugs PB Tarsa, CS Towler, G Woollam, J Berghausen European journal of pharmaceutical sciences 41 (1), 23-30, 2010 | 35 | 2010 |
| Lamellar phases under shear: variation of the layer orientation across the couette gap J Berghausen, J Zipfel, O Diat, T Narayanan, W Richtering Physical Chemistry Chemical Physics 2 (16), 3623-3626, 2000 | 33 | 2000 |
