Amy J Johnson
Amy J Johnson
Janssen Research and Development
Email yang diverifikasi di its.jnj.com
JudulDikutip olehTahun
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
JC Byrd, RR Furman, SE Coutre, IW Flinn, JA Burger, KA Blum, B Grant, ...
New England Journal of Medicine 369 (1), 32-42, 2013
17062013
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
JA Woyach, RR Furman, TM Liu, HG Ozer, M Zapatka, AS Ruppert, L Xue, ...
New England Journal of Medicine 370 (24), 2286-2294, 2014
6902014
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
SEM Herman, AL Gordon, E Hertlein, A Ramanunni, X Zhang, ...
Blood 117 (23), 6287-6296, 2011
6612011
CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
BJ Lannutti, SA Meadows, SEM Herman, A Kashishian, B Steiner, ...
Blood 117 (2), 591-594, 2011
6442011
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib
JC Byrd, RR Furman, SE Coutre, JA Burger, KA Blum, M Coleman, ...
Blood, blood-2014-10-606038, 2015
5902015
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival …
SEM Herman, AL Gordon, AJ Wagner, NA Heerema, W Zhao, JM Flynn, ...
Blood 116 (12), 2078-2088, 2010
5722010
Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial
S O'Brien, RR Furman, SE Coutre, JP Sharman, JA Burger, KA Blum, ...
The lancet oncology 15 (1), 48-58, 2014
5222014
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
AG Ramsay, AJ Johnson, AM Lee, G Gorgün, R Le Dieu, W Blum, JC Byrd, ...
The Journal of clinical investigation 118 (7), 2427-2437, 2008
5162008
Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia
JC Byrd, B Harrington, S O’Brien, JA Jones, A Schuh, S Devereux, ...
New England Journal of Medicine 374 (4), 323-332, 2016
4412016
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
JA Dubovsky, KA Beckwith, G Natarajan, JA Woyach, S Jaglowski, ...
Blood 122 (15), 2539-2549, 2013
4282013
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
JC Byrd, TS Lin, JT Dalton, D Wu, MA Phelps, B Fischer, M Moran, ...
Blood 109 (2), 399-404, 2006
4182006
Genetic heterogeneity of diffuse large B-cell lymphoma
J Zhang, V Grubor, CL Love, A Banerjee, KL Richards, PA Mieczkowski, ...
Proceedings of the National Academy of Sciences 110 (4), 1398-1403, 2013
4092013
The B-cell receptor signaling pathway as a therapeutic target in CLL
JA Woyach, AJ Johnson, JC Byrd
Blood 120 (6), 1175-1184, 2012
3512012
Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia
KJ Maddocks, AS Ruppert, G Lozanski, NA Heerema, W Zhao, L Abruzzo, ...
JAMA Oncology 1 (1), 80-87, 2015
3392015
Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells
X Song, HP Lin, AJ Johnson, PH Tseng, YT Yang, SK Kulp, CS Chen
Journal of the National Cancer Institute 94 (8), 585-591, 2002
3072002
Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
TS Lin, AS Ruppert, AJ Johnson, B Fischer, NA Heerema, LA Andritsos, ...
Journal of Clinical Oncology 27 (35), 6012-6018, 2009
2672009
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
JA Woyach, K Smucker, LL Smith, A Lozanski, Y Zhong, AS Ruppert, ...
Blood 123 (12), 1810-1817, 2014
2442014
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
R Lapalombella, Q Sun, K Williams, L Tangeman, S Jha, Y Zhong, ...
Blood 120 (23), 4621-4634, 2012
2222012
Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma
D Chiron, M Di Liberto, P Martin, X Huang, J Sharman, P Blecua, ...
Cancer discovery 4 (9), 1022-1035, 2014
1832014
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
MA Phelps, TS Lin, AJ Johnson, E Hurh, DM Rozewski, KL Farley, D Wu, ...
Blood 113 (12), 2637-2645, 2009
1732009
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