| Hsp90 mediates membrane deformation and exosome release E Lauwers, YC Wang, R Gallardo, R Van der Kant, E Michiels, J Swerts, ... Molecular cell 71 (5), 689-702. e9, 2018 | 136 | 2018 |
| Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90 RC Vasko, RA Rodriguez, CN Cunningham, VC Ardi, DA Agard, ... ACS medicinal chemistry letters 1 (1), 4-8, 2010 | 128 | 2010 |
| Cyclic peptides as drugs for intracellular targets: The next frontier in peptide therapeutic development LK Buckton, MN Rahimi, SR McAlpine Chemistry–A European Journal 27 (5), 1487-1513, 2021 | 111 | 2021 |
| Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets JR McConnell, SR McAlpine Bioorganic & medicinal chemistry letters 23 (7), 1923-1928, 2013 | 109 | 2013 |
| Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds MR Davis, EK Singh, H Wahyudi, LD Alexander, JB Kunicki, LA Nazarova, ... Tetrahedron 68 (4), 1029-1051, 2012 | 92 | 2012 |
| Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins VC Ardi, LD Alexander, VA Johnson, SR McAlpine ACS chemical biology 6 (12), 1357-1366, 2011 | 91 | 2011 |
| Halting metastasis through CXCR4 inhibition DM Ramsey, SR McAlpine Bioorganic & medicinal chemistry letters 23 (1), 20-25, 2013 | 88 | 2013 |
| Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives RP Sellers, LD Alexander, VA Johnson, CC Lin, J Savage, R Corral, ... Bioorganic & medicinal chemistry 18 (18), 6822-6856, 2010 | 85 | 2010 |
| N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes Y Wang, SR McAlpine Chemical communications 51 (8), 1410-1413, 2015 | 76 | 2015 |
| Comprehensive study of Sansalvamide A derivatives and their structure–activity relationships against drug-resistant colon cancer cell lines K Otrubova, G Lushington, D Vander Velde, KL McGuire, SR McAlpine Journal of medicinal chemistry 51 (3), 530-544, 2008 | 72 | 2008 |
| Studies of naphthyl-substituted β-cyclodextrins. Self-aggregation and inclusion of external guests SR McAlpine, MA Garcia-Garibay Journal of the American Chemical Society 120 (18), 4269-4275, 1998 | 71 | 1998 |
| Synthesis of second-generation sansalvamide A derivatives: novel templates as potential antitumor agents RA Rodriguez, PS Pan, CM Pan, S Ravula, S Lapera, EK Singh, TJ Styers, ... The Journal of organic chemistry 72 (6), 1980-2002, 2007 | 62 | 2007 |
| A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response JR McConnell, LA Alexander, SR McAlpine Bioorganic & medicinal chemistry letters 24 (2), 661-666, 2014 | 61 | 2014 |
| Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity EK Malle, NW Zammit, SN Walters, YC Koay, J Wu, BM Tan, ... Journal of Experimental Medicine 212 (8), 1239-1254, 2015 | 59 | 2015 |
| Visualizing Functional Group Distribution in Solid‐Support Beads by Using Optical Analysis SR McAlpine, SL Schreiber Chemistry–A European Journal 5 (12), 3528-3532, 1999 | 56 | 1999 |
| Inside− Outside Isomerism of β-Cyclodextrin Covalently Linked with a Naphthyl Group SR McAlpine, MA Garcia-Garibay Journal of the American Chemical Society 118 (11), 2750-2751, 1996 | 56 | 1996 |
| Macrocyclic inhibitors of hsp90 V A Johnson, E K Singh, L A Nazarova, L D Alexander, S R McAlpine Current topics in medicinal chemistry 10 (14), 1380-1402, 2010 | 53 | 2010 |
| Determination of functional group distribution within rasta resins utilizing optical analysis SR McAlpine, CW Lindsley, JC Hodges, DM Leonard, GF Filzen Journal of Combinatorial Chemistry 1 (3), 1-5, 2001 | 53 | 2001 |
| Total Synthesis of trans,trans-Sanguinamide B and Conformational Isomers EK Singh, DM Ramsey, SR McAlpine Organic letters 14 (5), 1198-1201, 2012 | 51 | 2012 |
| A comprehensive study of Sansalvamide A derivatives: The structure–activity relationships of 78 derivatives in two pancreatic cancer cell lines PS Pan, RC Vasko, SA Lapera, VA Johnson, RP Sellers, CC Lin, CM Pan, ... Bioorganic & medicinal chemistry 17 (16), 5806-5825, 2009 | 51 | 2009 |
Chung-Mao PanResearch Associate, The Scripps Research InstituteVerified email at scripps.edu
