Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation Y Hayashi, I Horiguchi, M Kino-oka, H Sugiyama Computers & Chemical Engineering 132, 106597, 2020 | 20 | 2020 |
Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells Y Hayashi, I Horiguchi, M Kino-oka, H Sugiyama Computers & Chemical Engineering 144, 107150, 2021 | 15 | 2021 |
A heterothermic kinetic model of hydrogen absorption in metals with subsurface transport S Ono, T Uchikoshi, Y Hayashi, Y Kitagawa, G Yeh, E Yamaguchi, ... Metals 9, 1131, 2019 | 12 | 2019 |
Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality Y Hayashi, M Kino-oka, H Sugiyama Computers & Chemical Engineering 156, 107566, 2022 | 8 | 2022 |
Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations Y Hayashi, Y Nakajima, H Sugiyama Cryobiology 100, 101-109, 2021 | 8 | 2021 |
A Dynamic and Probabilistic Design Space Determination Method for Mesenchymal Stem Cell Cultivation Processes K Hirono, I A. Udugama, Y Hayashi, M Kino-oka, H Sugiyama Industrial & Engineering Chemistry Research 61, 7009-7019, 2022 | 6 | 2022 |
Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis J Kim, Y Hayashi, S Badr, H Nakanishi, H Sugiyama Chemical Engineering Research and Design 189, 156-166, 2023 | 2 | 2023 |
An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan Y Hayashi, K Oishi, H Sugiyama Computer Aided Chemical Engineering 49, 2203-2208, 2022 | 2 | 2022 |
The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production IA Udugama, S Badr, K Hirono, BX Scholz, Y Hayashi, M Kino-oka, ... Computers & Chemical Engineering 172, 108144, 2023 | 1 | 2023 |
A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells BX Scholz, Y Hayashi, IA Udugama, M Kino-oka, H Sugiyama Computers & Chemical Engineering 163, 107851, 2022 | 1 | 2022 |
Design Space Determination of Mesenchymal Stem Cell Cultivation by Dynamic Modeling under Uncertainty K Hirono, IA Udugama, Y Hayashi, M Kino-oka, H Sugiyama Computer Aided Chemical Engineering 51, 721-726, 2022 | 1 | 2022 |
Multiobjective Dynamic Optimization of Slow Freezing Processes for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Condition Y Hayashi, I Horiguchi, M Kino-oka, H Sugiyama Computer Aided Chemical Engineering 48, 265-270, 2020 | 1 | 2020 |
Integrated white-box models for designing freezing processes of human induced pluripotent stem cells considering diversity within a container Y Hayashi, I Horiguchi, M Kino-oka, M Hirao, H Sugiyama Computer Aided Chemical Engineering 46, 877-882, 2019 | 1 | 2019 |
Computer-aided exploration of multiobjective optimal temperature profiles in slow freezing for human induced pluripotent stem cells Y Hayashi, Y Uno, M Kino-Oka, H Sugiyama Cryobiology, 104885, 2024 | | 2024 |
A Comprehensive Design Approach for Injectable Manufacturing Processes considering New Technologies and Operational Aspects M Yamada, S Badr, Y Hayashi, K Zenitani, K Kubota, H Nakanishi, ... Journal of Chemical Engineering of Japan 56 (1), 2201310, 2023 | | 2023 |
A Systems Evaluation Model for the Development of Companion Diagnostics and Associated Molecularly Targeted Therapies K Okamura, H Tsuchiya, R Hamada, Y Hayashi, S Badr, S Ohta, ... Journal of Pharmaceutical Innovation 18 (4), 2265-2276, 2023 | | 2023 |
Indicator-Based Supply Stability Analysis of Pharmaceutical Excipients: Method and Application K Nemoto, Y Hayashi, H Sugiyama 2023 AIChE Annual Meeting, 2023 | | 2023 |
Hybrid Modeling with Phase Contrast Microscopy Images for the Design of Mesenchymal Stem Cell Cultivation Processes K Hirono, Y Hayashi, IA Udugama, MR Gaddem, Y Takemoto, R Kato, ... 2023 AIChE Annual Meeting, 2023 | | 2023 |
Model-Based Design of the Next-Generation Decontamination Technology for Sterile Manufacturing MR Gaddem, Y Hayashi, H Futamura, K Kawasaki, H Sugiyama 2023 AIChE Annual Meeting, 2023 | | 2023 |
A Multilayered Approach to Continuous Freezing Process Design for Human Induced Pluripotent Stem Cells Y Hayashi, B Scholz, H Sugiyama 2023 AIChE Annual Meeting, 2023 | | 2023 |