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Yufeng Cai
Yufeng Cai
university of massachusetts
Verified email at umassmed.edu
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Molecular basis for drug resistance in HIV-1 protease
A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ...
Viruses 2 (11), 2509-2535, 2010
1722010
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease
DA Ragland, EA Nalivaika, MNL Nalam, KL Prachanronarong, H Cao, ...
Journal of the American Chemical Society 136 (34), 11956-11963, 2014
1052014
Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease
S Mittal, Y Cai, MNL Nalam, DNA Bolon, CA Schiffer
Journal of the American Chemical Society 134 (9), 4163-4168, 2012
832012
Differential flap dynamics in wild-type and a drug resistant variant of HIV-1 protease revealed by molecular dynamics and NMR relaxation
Y Cai, N Kurt Yilmaz, W Myint, R Ishima, CA Schiffer
Journal of chemical theory and computation 8 (10), 3452-3462, 2012
742012
Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV
Y Cai, CA Schiffer
Journal of chemical theory and computation 6 (4), 1358-1368, 2010
502010
Drug resistance mutations alter dynamics of inhibitor-bound HIV-1 protease
Y Cai, W Myint, JL Paulsen, CA Schiffer, R Ishima, N Kurt Yilmaz
Journal of chemical theory and computation 10 (8), 3438-3448, 2014
422014
SPOT‐Fold: Fragment‐Free Protein Structure Prediction Guided by Predicted Backbone Structure and Contact Map
Y Cai, X Li, Z Sun, Y Lu, H Zhao, J Hanson, K Paliwal, T Litfin, Y Zhou, ...
Journal of Computational Chemistry 41 (8), 745-750, 2020
112020
Modulation of HIV protease flexibility by the T80N mutation
H Zhou, S Li, J Badger, E Nalivaika, Y Cai, J Foulkes‐Murzycki, C Schiffer, ...
Proteins: Structure, Function, and Bioinformatics 83 (11), 1929-1939, 2015
102015
Quantitative comparison of errors in 15N transverse relaxation rates measured using various CPMG phasing schemes
W Myint, Y Cai, CA Schiffer, R Ishima
Journal of biomolecular NMR 53, 13-23, 2012
102012
Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease–DRV binding
Y Cai, C Schiffer
Computational Drug Discovery and Design, 551-560, 2012
82012
Analyses of accessory mutations in HIV-1 protease reveal interdependent mechanisms of resistance
DA Ragland, MNL Nalam, A Ozen, Y Cai, H Cao, CA Schiffer
ANTIVIRAL THERAPY 19, A155-A155, 2014
2014
Molecular Basis for Drug Resistance in HIV-1 Protease
CA Schiffer, K Thayer, EA Nalivaika, A Özen, MM Prabu-Jeyabalan, ...
2010
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Y Cai, S Nambi, CM Sassetti, F Wang, X Chen
2009
Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation
Y Cai
2009
Free Energy Calculation And Decomposition Of Hiv-1 Protease-Darunavir Binding By MM-PB/GBSA And Thermodynamic Integration Method
Y Cai
Biophysical Journal 96 (3), 85a, 2009
2009
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