| Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor J Garcia Fortanet, CHT Chen, YNP Chen, Z Chen, Z Deng, B Firestone, ... Journal of medicinal chemistry 59 (17), 7773-7782, 2016 | 259 | 2016 |
| Impact of molecular speciation on crystal nucleation in polymorphic systems: The conundrum of γ glycine and molecular ‘self poisoning' CS Towler, RJ Davey, RW Lancaster, CJ Price Journal of the American Chemical Society 126 (41), 13347-13353, 2004 | 221 | 2004 |
| Crystallization in polymorphic systems: the solution-mediated transformation of β to α glycine ES Ferrari, RJ Davey, WI Cross, AL Gillon, CS Towler Crystal growth & design 3 (1), 53-60, 2003 | 188 | 2003 |
| Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer MJ LaMarche, M Acker, A Argintaru, D Bauer, J Boisclair, H Chan, ... Journal of medicinal chemistry 63 (22), 13578-13594, 2020 | 130 | 2020 |
| Discovery of small molecule splicing modulators of survival motor neuron-2 (SMN2) for the treatment of spinal muscular atrophy (SMA) AK Cheung, B Hurley, R Kerrigan, L Shu, DN Chin, Y Shen, G O’Brien, ... Journal of medicinal chemistry 61 (24), 11021-11036, 2018 | 122 | 2018 |
| The crystallization of glycine polymorphs from emulsions, microemulsions, and lamellar phases K Allen, RJ Davey, E Ferrari, C Towler, GJ Tiddy, MO Jones, RG Pritchard Crystal growth & design 2 (6), 523-527, 2002 | 97 | 2002 |
| 6-Amino-3-methylpyrimidinones as potent, selective, and orally efficacious SHP2 inhibitors P Sarver, M Acker, JT Bagdanoff, Z Chen, YN Chen, H Chan, B Firestone, ... Journal of medicinal chemistry 62 (4), 1793-1802, 2019 | 83 | 2019 |
| Optimization of fused bicyclic allosteric SHP2 inhibitors JT Bagdanoff, Z Chen, M Acker, YN Chen, H Chan, M Dore, B Firestone, ... Journal of medicinal chemistry 62 (4), 1781-1792, 2019 | 66 | 2019 |
| An investigation into the influence of counterion on the properties of some amorphous organic salts CS Towler, T Li, H Wikström, DM Remick, MV Sanchez-Felix, LS Taylor Molecular pharmaceutics 5 (6), 946-955, 2008 | 37 | 2008 |
| The influence of aqueous content in small scale salt screening—improving hit rate for weakly basic, low solubility drugs PB Tarsa, CS Towler, G Woollam, J Berghausen European journal of pharmaceutical sciences 41 (1), 23-30, 2010 | 35 | 2010 |
| Spectroscopic characterization of intermolecular interactions in solution and their influence on crystallization outcome CS Towler, LS Taylor Crystal growth & design 7 (4), 633-638, 2007 | 33 | 2007 |
| A novel selective soluble guanylate cyclase activator, MGV354, lowers intraocular pressure in preclinical models, following topical ocular dosing G Prasanna, L Ferrara, C Adams, T Ehara, B Li, L Yang, C Xiang, CTH Ng, ... Investigative Ophthalmology & Visual Science 59 (5), 1704-1716, 2018 | 19 | 2018 |
| The Discovery of (S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-5-methyl-1H-pyrazole-4 … T Ehara, CM Adams, D Bevan, N Ji, EL Meredith, DB Belanger, J Powers, ... Journal of medicinal chemistry 61 (6), 2552-2570, 2018 | 15 | 2018 |
| Quinazolinone derivatives useful as vanilloid antagonists W Chen, HY Kim, J Liang, M Mutz, M Prashad, C Towler, R Wu US Patent 8,349,852, 2013 | 8 | 2013 |
| R. f. Da2ey, RX kancaster, C. f. Price, Impact o> Molecular Speciation on Crystal Nucleation in Polymorphic SystemsI The Conundrum o>" Glycine and Molecular xSel> Poisoningx CS Towler Journal of the American Chemical Society 126, 13347, 2004 | 7 | 2004 |
| Counterion quantification for discovery chemistry and pre-formulation salt screening J Reilly, P Wright, J Larrow, T Mann, J Twomey, M Grondine, S Dodd, ... Journal of liquid chromatography & related technologies 35 (8), 1001-1010, 2012 | 4 | 2012 |
| Early Intervention with Formulation Strategies for Multidimensional Problems to Optimize for Success S Dodd, C Capacci‐Daniel, C Towler, R Panicucci, K Hoffmaster Predictive ADMET: Integrative Approaches in Drug Discovery and Development …, 2014 | 1 | 2014 |
| Nucleation in polymorphic systems C Towler The University of Manchester, 2004 | 1 | 2004 |
| Derivados de quinazolinona útiles como antagonistas de vanilloides W Chen, HY Kim, J Liang, M Mutz, M Prashad, C Towler, R Wu | | 2017 |
| Quinazolinone derivatives useful as vanilloid antagonists W Chen, HY Kim, J Liang, M Mutz, M Prashad, C Towler, R Wu US Patent App. 13/612,259, 2013 | | 2013 |
