Bruno Guigas
Bruno Guigas
Leiden University Medical Center
Email yang diverifikasi di - Beranda
Dikutip oleh
Dikutip oleh
Cellular and molecular mechanisms of metformin: an overview
B Viollet, B Guigas, NS Garcia, J Leclerc, M Foretz, F Andreelli
Clinical science 122 (6), 253-270, 2012
Metformin: from mechanisms of action to therapies
M Foretz, B Guigas, L Bertrand, M Pollak, B Viollet
Cell metabolism 20 (6), 953-966, 2014
Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
B Viollet, M Foretz, B Guigas, S Horman, R Dentin, L Bertrand, L Hue, ...
The Journal of physiology 574 (1), 41-53, 2006
AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
B Viollet, B Guigas, J Leclerc, S Hébrard, L Lantier, R Mounier, F Andreelli, ...
Acta physiologica 196 (1), 81-98, 2009
AMPK: Lessons from transgenic and knockout animals
B Viollet, Y Athea, R Mounier, B Guigas, E Zarrinpashneh, S Horman, ...
Frontiers in bioscience (Landmark edition) 14, 19, 2009
Metformin prevents high-glucose–induced endothelial cell death through a mitochondrial permeability transition-dependent process
D Detaille, B Guigas, C Chauvin, C Batandier, E Fontaine, ...
Diabetes 54 (7), 2179-2187, 2005
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
X Stephenne, M Foretz, N Taleux, GC Van der Zon, E Sokal, L Hue, ...
Diabetologia 54 (12), 3101-3110, 2011
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin
C Batandier, B Guigas, D Detaille, M El-Mir, E Fontaine, M Rigoulet, ...
Journal of bioenergetics and biomembranes 38 (1), 33-42, 2006
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons
MY El-Mir, D Detaille, R Gloria, M Delgado-Esteban, B Guigas, S Attia, ...
Journal of Molecular Neuroscience 34 (1), 77-87, 2008
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase–independent effect on glucokinase …
B Guigas, L Bertrand, N Taleux, M Foretz, N Wiernsperger, D Vertommen, ...
Diabetes 55 (4), 865-874, 2006
Role of AMP kinase and PPARδ in the regulation of lipid and glucose metabolism in human skeletal muscle
DK Krämer, L Al-Khalili, B Guigas, Y Leng, PM Garcia-Roves, A Krook
Journal of Biological Chemistry 282 (27), 19313-19320, 2007
Mitochondrial metabolism and type-2 diabetes: a specific target of metformin
XM Leverve, B Guigas, D Detaille, C Batandier, EA Koceir, C Chauvin, ...
Diabetes & metabolism 29 (4), 6S88-6S94, 2003
Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study
B Guigas, D Detaille, C Chauvin, C Batandier, F De Oliveira, E Fontaine, ...
Biochemical journal 382 (3), 877-884, 2004
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
L Bertrand, A Ginion, C Beauloye, AD Hebert, B Guigas, L Hue, ...
American Journal of Physiology-Heart and Circulatory Physiology 291 (1 …, 2006
Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice
L Hussaarts, N García‐Tardón, L van Beek, MM Heemskerk, S Haeberlein, ...
The FASEB Journal 29 (7), 3027-3039, 2015
Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice
JJ Geerling, MR Boon, GC van der Zon, SAA van den Berg, ...
Diabetes 63 (3), 880-891, 2014
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
B Guigas, N Taleux, M Foretz, D Detaille, F Andreelli, B Viollet, L Hue
Biochemical Journal 404 (3), 499-507, 2007
Gene expression analysis of mTOR pathway: association with human longevity
WM Passtoors, M Beekman, J Deelen, R van der Breggen, AB Maier, ...
Aging Cell 12 (1), 24-31, 2013
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function
D Detaille, B Guigas, X Leverve, N Wiernsperger, P Devos
Biochemical pharmacology 63 (7), 1259-1272, 2002
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts
N Van Leeuwen, G Nijpels, ML Becker, H Deshmukh, K Zhou, ...
Diabetologia 55 (7), 1971-1977, 2012
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