David M. Smith
Cited by
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Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
S Nam, DM Smith, QP Dou
Journal of Biological Chemistry 276 (16), 13322-13330, 2001
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's α ring opens the gate for substrate entry
DM Smith, SC Chang, S Park, D Finley, Y Cheng, AL Goldberg
Molecular cell 27 (5), 731-744, 2007
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases
J Rabl, DM Smith, Y Yu, SC Chang, AL Goldberg, Y Cheng
Molecular cell 30 (3), 360-368, 2008
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins
DM Smith, G Kafri, Y Cheng, D Ng, T Walz, AL Goldberg
Molecular cell 20 (5), 687-698, 2005
Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein
A Kazi, KG Daniel, DM Smith, NB Kumar, QP Dou
Biochemical pharmacology 66 (6), 965-976, 2003
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle
DM Smith, H Fraga, C Reis, G Kafri, AL Goldberg
Cell 144 (4), 526-538, 2011
Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis
S Nam, DM Smith, QP Dou
Cancer Epidemiology and Prevention Biomarkers 10 (10), 1083-1088, 2001
Synthetic analogs of green tea polyphenols as proteasome inhibitors
DM Smith, Z Wang, A Kazi, L Li, TH Chan, QP Dou
Molecular medicine 8 (7), 382-392, 2002
Proteasomes and their associated ATPases: a destructive combination
DM Smith, N Benaroudj, A Goldberg
Journal of structural biology 156 (1), 72-83, 2006
A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
TA Thibaudeau, RT Anderson, DM Smith
Nature communications 9 (1), 1-14, 2018
Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design
DM Smith, KG Daniel, Z Wang, WC Guida, TH Chan, QP Dou
Proteins: Structure, Function, and Bioinformatics 54 (1), 58-70, 2004
A practical review of proteasome pharmacology
TA Thibaudeau, DM Smith
Pharmacological reviews 71 (2), 170-197, 2019
Interactions of PAN's C‐termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions
Y Yu, DM Smith, HM Kim, V Rodriguez, AL Goldberg, Y Cheng
The EMBO journal 29 (3), 692-702, 2010
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
P Deriziotis, R André, DM Smith, R Goold, KJ Kinghorn, M Kristiansen, ...
The EMBO journal 30 (15), 3065-3077, 2011
Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention.
A Kazi, DM Smith, K Daniel, S Zhong, P Gupta, ME Bosley, QP Dou
In Vivo (Athens, Greece) 16 (6), 397-403, 2002
A novel β-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage
DM Smith, A Kazi, L Smith, TE Long, B Heldreth, E Turos, QP Dou
Molecular pharmacology 61 (6), 1348-1358, 2002
A conserved F box regulatory complex controls proteasome activity in Drosophila
M Bader, S Benjamin, OL Wapinski, DM Smith, AL Goldberg, H Steller
Cell 145 (3), 371-382, 2011
Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis
DM Smith, QP Dou
International journal of molecular medicine 7 (6), 645-652, 2001
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism
T Dange, D Smith, T Noy, PC Rommel, L Jurzitza, RJB Cordero, ...
Journal of Biological Chemistry 286 (50), 42830-42839, 2011
Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy
QP Dou, DM Smith, KG Daniel, A Kazi
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