| Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ... Cell 149 (2), 307-321, 2012 | 828 | 2012 |
| Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. LM Graves, KE Bornfeldt, EW Raines, BC Potts, SG Macdonald, R Ross, ... Proceedings of the National Academy of Sciences 90 (21), 10300-10304, 1993 | 562 | 1993 |
| Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from … KE Bornfeldt, EW Raines, T Nakano, LM Graves, EG Krebs, R Ross The Journal of clinical investigation 93 (3), 1266-1274, 1994 | 499 | 1994 |
| Activation of a novel calcium-dependent protein-tyrosine kinase: correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation H Yu, X Li, GS Marchetto, R Dy, D Hunter, B Calvo, TL Dawson, M Wilm, ... Journal of Biological Chemistry 271 (47), 29993-29998, 1996 | 351 | 1996 |
| Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ... Cell reports 11 (3), 390-404, 2015 | 334 | 2015 |
| Activation of MAPKs in human bronchial epithelial cells exposed to metals JM Samet, LM Graves, J Quay, LA Dailey, RB Devlin, AJ Ghio, W Wu, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 275 (3 …, 1998 | 331 | 1998 |
| Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. KE Bornfeldt, LM Graves, EW Raines, Y Igarashi, G Wayman, ... The Journal of cell biology 130 (1), 193-206, 1995 | 320 | 1995 |
| Regulation of carbamoyl phosphate synthetase by MAP kinase LM Graves, HI Guy, P Kozlowski, M Huang, E Lazarowski, RM Pope, ... Nature 403 (6767), 328-332, 2000 | 296 | 2000 |
| Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. KE Bornfeldt, EW Raines, LM Graves, MP Skinner, EG Krebs, R Ross Annals of the New York Academy of Sciences 766, 416-430, 1995 | 277 | 1995 |
| cAMP-and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. LM Graves, KE Bornfeldt, GM Argast, EG Krebs, X Kong, TA Lin, ... Proceedings of the National Academy of Sciences 92 (16), 7222-7226, 1995 | 259 | 1995 |
| Chronic e-cigarette exposure alters the human bronchial epithelial proteome A Ghosh, RC Coakley, T Mascenik, TR Rowell, ES Davis, K Rogers, ... American journal of respiratory and critical care medicine 198 (1), 67-76, 2018 | 252 | 2018 |
| Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. R Seger, D Seger, FJ Lozeman, NG Ahn, LM Graves, JS Campbell, ... Journal of Biological Chemistry 267 (36), 25628-25631, 1992 | 242 | 1992 |
| Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals W Wu, LM Graves, I Jaspers, RB Devlin, W Reed, JM Samet American Journal of Physiology-Lung Cellular and Molecular Physiology 277 (5 …, 1999 | 224 | 1999 |
| Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation W Wu, LM Graves, GN Gill, SJ Parsons, JM Samet Journal of Biological Chemistry 277 (27), 24252-24257, 2002 | 188 | 2002 |
| Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G–protein coupled receptor–EGF receptor transactivation pathway X Li, JW Lee, LM Graves, HS Earp The EMBO journal 17 (9), 2574-2583, 1998 | 186 | 1998 |
| The MAP kinase cascade JS Campbell, R Seger, JD Graves, LM Graves, AM Jensen, EG Krebs Proceedings of the 1993 Laurentian Hormone Conference, 131-159, 1995 | 180 | 1995 |
| MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression GL Johnson, HG Dohlman, LM Graves Current opinion in chemical biology 9 (3), 325-331, 2005 | 172 | 2005 |
| Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex JS Zawistowski, SM Bevill, DR Goulet, TJ Stuhlmiller, AS Beltran, ... Cancer discovery 7 (3), 302-321, 2017 | 149 | 2017 |
| Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells YM Kim, W Reed, W Wu, PA Bromberg, LM Graves, JM Samet American Journal of Physiology-Lung Cellular and Molecular Physiology 290 (5 …, 2006 | 143 | 2006 |
| KRAS suppression-induced degradation of MYC is antagonized by a MEK5-ERK5 compensatory mechanism AV Vaseva, DR Blake, TSK Gilbert, S Ng, G Hostetter, SH Azam, ... Cancer cell 34 (5), 807-822. e7, 2018 | 142 | 2018 |
Laura E HerringDirector of UNC Proteomics Core Facility, UNC-Chapel HillVerified email at med.unc.edu
