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Mark Leick
Mark Leick
Harvard Medical School
Email yang diverifikasi di mgh.harvard.edu
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CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
BD Choi, X Yu, AP Castano, AA Bouffard, A Schmidts, RC Larson, ...
Nature biotechnology 37 (9), 1049-1058, 2019
4102019
CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma
BD Choi, X Yu, AP Castano, H Darr, DB Henderson, AA Bouffard, ...
Journal for immunotherapy of cancer 7, 1-8, 2019
2442019
Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma
MJ Frigault, J Dietrich, M Martinez-Lage, M Leick, BD Choi, Z DeFilipp, ...
Blood, The Journal of the American Society of Hematology 134 (11), 860-866, 2019
2142019
CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
RC Larson, MC Kann, SR Bailey, NJ Haradhvala, PM Llopis, AA Bouffard, ...
Nature 604 (7906), 563-570, 2022
1862022
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma
Nature Medicine, 2022
982022
Safety and efficacy of tisagenlecleucel in primary CNS lymphoma: a phase 1/2 clinical trial
MJ Frigault, J Dietrich, K Gallagher, M Roschewski, JT Jordan, D Forst, ...
Blood, The Journal of the American Society of Hematology 139 (15), 2306-2315, 2022
782022
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia
MB Leick, H Silva, I Scarfò, R Larson, BD Choi, AA Bouffard, K Gallagher, ...
Cancer cell 40 (5), 494-508. e5, 2022
642022
Single-center experience using anakinra for steroid-refractory immune effector cell-associated neurotoxicity syndrome (ICANS)
M Wehrli, K Gallagher, YB Chen, MB Leick, SL McAfee, AR El-Jawahri, ...
Journal for immunotherapy of cancer 10 (1), 2022
622022
Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer
MB Leick, CJ Shoff, EC Wang, JL Congress, GI Gallicano
American journal of stem cells 1 (1), 59, 2012
622012
Blockade or deletion of IFNγ reduces macrophage activation without compromising CAR T-cell function in hematologic malignancies
SR Bailey, S Vatsa, RC Larson, AA Bouffard, I Scarfò, MC Kann, ...
Blood Cancer Discovery 3 (2), 136-153, 2022
562022
Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy
PG Miller, AS Sperling, EJ Brea, MB Leick, GG Fell, M Jan, SH Gohil, ...
Blood advances 5 (15), 2982-2986, 2021
542021
Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome
MR Hines, TE Knight, KO McNerney, MB Leick, T Jain, S Ahmed, ...
Transplantation and Cellular Therapy 29 (7), 438. e1-438. e16, 2023
512023
The future of targeting FLT3 activation in AML
MB Leick, MJ Levis
Current hematologic malignancy reports 12, 153-167, 2017
512017
SARS-CoV-2 T-cell immunity to variants of concern following vaccination
KME Gallagher, MB Leick, RC Larson, TR Berger, K Katsis, JY Yam, ...
BioRxiv, 2021
382021
Clinical perspective: treatment of aggressive B cell lymphomas with FDA-approved CAR-T cell therapies
MB Leick, MV Maus, MJ Frigault
Molecular Therapy 29 (2), 433-441, 2021
242021
Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources
A Schmidts, LC Marsh, AA Srivastava, AA Bouffard, AC Boroughs, I Scarfò, ...
Journal for immunotherapy of cancer 8 (2), 2020
202020
Toxicities associated with immunotherapies for hematologic malignancies
MB Leick, MV Maus
Best Practice & Research Clinical Haematology 31 (2), 158-165, 2018
182018
HIV-associated hematological malignancies
M Hentrich, SK Barta
Springer, 2016
172016
Dose-finding study of hepatic arterial infusion of oxaliplatin-based treatment in patients with advanced solid tumors metastatic to the liver
AM Tsimberidou, MB Leick, J Lim, S Fu, J Wheler, SA Piha-Paul, D Hong, ...
Cancer chemotherapy and pharmacology 71, 389-397, 2013
172013
T cell clonal dynamics determined by high-resolution TCR-β sequencing in recipients after allogeneic hematopoietic cell transplantation
M Leick, RM Gittelman, E Yusko, C Sanders, H Robins, Z DeFilipp, ...
Biology of Blood and Marrow Transplantation 26 (9), 1567-1574, 2020
142020
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