| A liver-derived secretory protein, selenoprotein P, causes insulin resistance H Misu, T Takamura, H Takayama, H Hayashi, N Matsuzawa-Nagata, ... Cell metabolism 12 (5), 483-495, 2010 | 594 | 2010 |
| Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria S Nakamura, T Takamura, N Matsuzawa-Nagata, H Takayama, H Misu, ... Journal of Biological Chemistry 284 (22), 14809-14818, 2009 | 495 | 2009 |
| Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, ... Nature medicine 23 (4), 508-516, 2017 | 149 | 2017 |
| LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance F Lan, H Misu, K Chikamoto, H Takayama, A Kikuchi, K Mohri, N Takata, ... Diabetes 63 (5), 1649-1664, 2014 | 148 | 2014 |
| Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver T Otoda, T Takamura, H Misu, T Ota, S Murata, H Hayashi, H Takayama, ... Diabetes 62 (3), 811-824, 2013 | 147 | 2013 |
| Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes H Takayama, H Misu, H Iwama, K Chikamoto, Y Saito, K Murao, ... Journal of Biological Chemistry 289 (1), 335-345, 2014 | 84 | 2014 |
| Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells K Ishikura, H Misu, M Kumazaki, H Takayama, N Matsuzawa-Nagata, ... Diabetologia 57, 1968-1976, 2014 | 76 | 2014 |
| The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men JA Sargeant, GP Aithal, T Takamura, H Misu, H Takayama, JA Douglas, ... Applied Physiology, Nutrition, and Metabolism 43 (5), 482-490, 2018 | 72 | 2018 |
| Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population SM Oo, H Misu, Y Saito, M Tanaka, S Kato, Y Kita, H Takayama, ... Scientific Reports 8 (1), 16727, 2018 | 58 | 2018 |
| Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 … N Tajima-Shirasaki, K Ishii, H Takayama, T Shirasaki, H Iwama, ... Journal of Biological Chemistry 292 (26), 10791-10800, 2017 | 40 | 2017 |
| LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH N Takata, K Ishii, H Takayama, M Nagashimada, K Kamoshita, T Tanaka, ... Scientific Reports 11 (1), 555, 2021 | 39 | 2021 |
| Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice K Chikamoto, H Misu, H Takayama, A Kikuchi, K Ishii, F Lan, N Takata, ... Biochemical and biophysical research communications 478 (3), 1310-1316, 2016 | 39 | 2016 |
| Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men SA Willis, JA Sargeant, T Yates, T Takamura, H Takayama, V Gupta, ... The Journal of Nutrition 150 (5), 1076-1085, 2020 | 35 | 2020 |
| Comparison of human selenoprotein P determinants in serum between our original methods and commercially available kits Y Saito, H Misu, H Takayama, S Takashima, S Usui, M Takamura, ... Biological and Pharmaceutical Bulletin 41 (5), 828-832, 2018 | 33 | 2018 |
| Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat SM Oo, HK Oo, H Takayama, K Ishii, Y Takeshita, H Goto, Y Nakano, ... Cell Reports 38 (13), 2022 | 16 | 2022 |
| Alcohol intake is associated with elevated serum levels of selenium and selenoprotein P in humans Y Isobe, H Asakura, H Tsujiguchi, T Kannon, H Takayama, Y Takeshita, ... Frontiers in nutrition 8, 633703, 2021 | 12 | 2021 |
| Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET T Shirasaki, S Yamagoe, T Shimakami, K Murai, R Imamura, KA Ishii, ... Nature Communications 13 (1), 3176, 2022 | 7 | 2022 |
| Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans K Mohri, H Misu, H Takayama, K Ishii, A Kikuchi, F Lan, Y Enyama, ... Biological and Pharmaceutical Bulletin 42 (3), 373-378, 2019 | 7 | 2019 |
| Trajectories of liver fibrosis and gene expression profiles in nonalcoholic fatty liver disease associated with diabetes S Sako, Y Takeshita, H Takayama, H Goto, Y Nakano, H Ando, ... Diabetes 72 (9), 1297-1306, 2023 | 6 | 2023 |
| Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice A Kikuchi, H Takayama, H Tsugane, K Shiba, K Chikamoto, T Yamamoto, ... Scientific Reports 10 (1), 13260, 2020 | 5 | 2020 |
Yoshiro Saito （斎藤芳郎）Tohoku UniversityEmail yang diverifikasi di tohoku.ac.jp
